Expression characteristics and diagnostic value of annexin A2 in hepatocellular carcinoma
نویسندگان
چکیده
منابع مشابه
Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma.
Annexins (ANXs) constitute a family of Ca2+-dependent membrane-binding proteins; at least 20 of them have been described to date. Among these, Annexin A2 (ANXA2) has been revealed as a multi-functional protein in vitro. Its actual role in vivo, however, requires further investigation. We already reported that ANX-I (ANXA1) was up-regulated in hepatocellular carcinoma (HCC). The role of ANXA2 in...
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BACKGROUND/AIMS We tried to investigate the expression characteristics of KAI1, a suppressor of wide-spectrum tumor metastasis, and vascular endothelial growth factor (VEGF), the most common angiogenesis factor, and then to analyze their diagnostic value for hepatocellular carcinoma (HCC). METHODS The protein and mRNA expression levels of KAI1 or VEGF in HCC tissues and in self-controlled par...
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OBJECTIVE Over-expression of annexin A2 (ANXA2) has been reported in various cancers. However, no data are available on the expression of this protein in head and neck squamous cell carcinomas (HNSCC). The objective of this preliminary study is to investigate the expression of ANXA2 in these carcinomas. MATERIAL AND METHOD ANXA2 expression was analyzed by immunohistochemistry in paraffin-embe...
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The ubiquitin-dependent proteasomal degradation of proteins controls signaling and cellular survival. In this study, we found that ubiquitin associated protein 2 (UBAP2) was significantly downregulated in hepatocellular carcinoma (HCC) tissues compared with adjacent normal tissues. Furthermore, higher expression of UBAP2 in cancer tissues was correlated with good prognosis in HCC patients. Knoc...
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conclusions the findings of this study reveal that both arg-1 and gpc-3 are helpful ihc markers to separate hcc from cc and ma. furthermore, arg-1 shows 100% sensitivity and 82.6% specificity for the diagnosis of hcc whereas gpc-3 demonstrated 97.7% sensitivity and 91.3% specificity for the diagnosis of this tumor. results arginase-1 and gpc-3 demonstrated diffuse staining, as reactivity in > 9...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2012
ISSN: 1007-9327
DOI: 10.3748/wjg.v18.i41.5897